The pancreas sits at the crossroads of digestion and metabolism, and its disorders range from acute inflammatory crises to chronic exocrine and endocrine failure. This book explains the spectrum of pancreatic disease — acute and chronic pancreatitis, cystic lesions, and pancreatic neoplasms — in a clinically focused, accessible way. Chapters cover pathophysiology, key diagnostic tests (enzymes, imaging, endoscopy), and the modern role of cross-sectional and endoscopic ultrasound. Management sections balance medical therapy, endoscopic interventions, and surgical options with attention to nutritional support and pain control. Special topics include pancreatic exocrine insufficiency, diabetes secondary to pancreatic disease, and approaches to complex cystic lesions. Designed for gastroenterologists, surgeons, and trainees who need pragmatic guidance for diagnosis and multidisciplinary care.