General medicine studies the broad spectrum of adult illnesses, integrating pathophysiology with practical clinical reasoning across body systems. This volume focuses on the core systems—cardiac, pulmonary, renal, gastrointestinal and neurologic—and the common presentations that clinicians encounter daily. It explains how to gather focused histories, perform efficient examinations, and interpret basic investigations with clinical judgment. Each chapter links pathophysiologic mechanisms to bedside decision-making and outpatient management priorities. Concise algorithms, checklists and quick-reference tables make the information immediately usable in busy clinics. The book is pitched at trainees and early-career physicians seeking a dependable, system-based reference.