General medicine increasingly requires procedural skills and the ability to manage complex, multi-morbidity patients safely. Volume 2 builds on core knowledge to teach practical competencies: procedural techniques, acute care algorithms, and specialty coordination. It covers hands-on topics—vascular access, pleural procedures, emergency airway management—alongside guidance on frailty, polypharmacy and care transitions. Emphasis is placed on procedural indications, stepwise technique, complication recognition and remediation. Simulation tips, consent and documentation templates, and competency checklists help clinicians develop safe practice habits. The handbook is aimed at general physicians, hospitalists and trainees sharpening procedural and systems-based skills.